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Using a computational model, Radhika Nagpal and her collaborators demonstrated that the regularity of epithelial tissues, e.g., the percentage of hexagons, can act as an indicator for inferring properties about how cells divide.

Image courtesy Radhika Nagpal, Harvard School of Engineering and Applied Sciences

Computer scientists model cell division

Computer scientists at Harvard have developed a framework for studying the arrangement of tissue networks created by cell division across a diverse set of organisms, including fruit flies, tadpoles, and plants.

The finding, published in the June 2009 issue of PLoS Computational Biology, could lead to insights about how multicellular systems achieve (or fail to achieve) robustness from the seemingly random behavior of groups of cells, and provide a road map for researchers seeking to artificially emulate complex biological behavior.

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