genetics

“These results represent a new way of targeting oncogenes that have been refractory to standard treatments,” said senior author of the report William Hahn of Dana-Farber, the Broad Institute, and Harvard Medical School (HMS). “What’s particularly exciting is that this approach is potentially highly specific to cancer cells, and therefore should have little toxicity to normal tissues.”

Researchers exploit genetic ‘co-dependence’ to kill treatment-resistant tumor cells

Cancer cells fueled by the mutant KRAS oncogene, which makes them notoriously difficult to treat, can be killed by blocking a more vulnerable genetic partner of KRAS, report scientists at the Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT.

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